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Chemotherapy-induced metastasis
Tumors often overcome the cytotoxic effects of chemotherapy through
either acquired or environment-mediated drug resistance. In addition, signals
from the microenvironment obfuscate the beneficial effects of chemotherapy and
may facilitate progression and metastatic dissemination. Seminal mediators in
chemotherapy-induced metastasis appear to be a wide range of hematopoietic,
mesenchymal and immune progenitor cells, originating from the bone marrow. The
actual purpose of these cells is to orchestrate the repair response to the
cytotoxic damage of chemotherapy. However, these repair responses are exploited
by tumor cells at every step of the metastatic cascade, ranging from tumor cell
invasion, intravasation and hematogenous dissemination to extravasation and
effective colonization at the metastatic site. A better understanding of the
mechanistic underpinnings of chemotherapy-induced metastasis will allow us to
better predict which patients are more likely to exhibit pro-metastatic
responses to chemotherapy and will help develop new therapeutic strategies to
neutralize chemotherapy-driven prometastatic changes.
ΠΗΓΗ: Karagiannis G. S., Condeelis
J. S., Oktay M. H. «Chemotherapy-induced metastasis: mechanisms and translational opportunities», στο Clin Exp
Metastasis. 2018 Apr; 35(4):269-284. doi:
10.1007/s10585-017-9870-x. Epub 2018 Jan 6.
ΑΡΧΕΙΟΝ ΠΟΛΙΤΙΣΜΟΥ, 7.10.2019.
ΛΕΞΕΙΣ: Μετασταση, χημειοθεραπεια, καρκινος
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